Advanced Glycation Inhibitory Potential of Certain Antidiabetic Plants book

Advanced Glycation Inhibitory Potential of Certain Antidiabetic Plants book

Advanced Glycation Inhibitory Potential of Certain Antidiabetic Plants by Singh Nirmal

Advanced Glycation Inhibitory Potential of Certain Antidiabetic Plants
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Author: Singh Nirmal
Number of Pages: 64 pages
Published Date: 02 Aug 2014
Publisher: LAP Lambert Academic Publishing
Publication Country: United States
Language: English
ISBN: 9783659566332
Download Link: advanced glycation inhibitory potential of certain antidiabetic plants
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The present study was designed to investigate the antiglycation potential of hydro-alcoholic and alkaloidal fractions of selected plants. Seeds of Trigonella foenum-graecum, bulbs of Allium sativum, fruits of Momordica charantia. and leaves of Gymnema sylvestre were selected. The protein glycation inhibitory activity of these plants was evaluated using glucose-bovine serum albumin assay. Among the hydroalcoholic extracts, Trigonella-foenum graecum showed highest antiglycation activity (IC50 = 53.53 1.24 ug/ml) followed by Allium sativum (IC50 = 68.36 1.56 ug/ml), Momordica charantia (IC50 = 85.16 1.87 ug/ml) and Gymnema sylvestre (IC50 = 103.66 2.09 ug/ml). Among the alkaloidal fractions, the highest antiglycation activity was shown by Trigonella-foenum graecum (IC50 = 31.56 1.36 ug/ml) followed by Allium sativum (IC50 = 40.46 1.59 ug/ml), Momordica charantia (IC50 = 54.8 2.12 ug/ml) and Gymnema sylvestre (IC50 = 64.50 1.73 ug/ml). Aminoguanidine, a standard drug, showed 100% inhibition (IC50 = 22.45 1.89 ug/ml). Alkaloidal extracts of these plants possess antiglycation activity and may be explored in diabetic complications

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